G-CSF-Treated Donor Bone Marrow Transplant in Treating Patients With Hematologic Disorders

Overview

RATIONALE: Giving chemotherapy drugs and total-body irradiation before a donor bone marrow transplant helps stop the growth of cancer and abnormal cells and helps stop the patient's immune system from rejecting the donor's stem cells. When the healthy stem cells from a donor are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. Giving colony-stimulating factors, such as G-CSF, to the donor helps the stem cells move from the bone marrow to the blood so they can be collected and stored. PURPOSE: This clinical trial is studying how well a G-CSF-treated donor bone marrow transplant works in treating patients with hematologic cancer or noncancer.

OBJECTIVES: Primary * Determine whether granulocyte engraftment can be achieved by day 30 in patients with hematologic disorders undergoing HLA-matched, related-donor, allogeneic bone marrow transplantation using filgrastim (G-CSF)-primed bone marrow. * Determine the incidence of grade II or greater acute graft-versus-host disease (GVHD) in patients treated with this regimen and post-transplantation immunosuppression with cyclosporine and methotrexate. Secondary * Determine whether platelet and red blood cell engraftment can be achieved in patients treated with this regimen. * Determine the incidence of limited and extensive chronic GVHD in patients treated with this regimen. * Determine the event-free survival of patients treated with this regimen. * Determine the post-transplant immune reconstitution in patients treated with this regimen. OUTLINE: This is a pilot study. * Mobilization: Donors receive filgrastim (G-CSF) subcutaneously (SC) daily on days -3 to -1 followed by bone marrow collection. * Conditioning regimen: Patients receive 1 of the following conditioning regimens according to their primary disease: * Total-body irradiation and high-dose chemotherapy comprising etoposide and cyclophosphamide * High-dose chemotherapy comprising busulfan and cyclophosphamide * Bone marrow transplantation: Patients receive G-CSF-primed allogeneic bone marrow on day 0. Patients then receive G-CSF SC beginning on day 5. * Graft-versus-host disease prophylaxis: Patients receive cyclosporine beginning on day -1 and methotrexate on days 1, 3, and 6. PROJECTED ACCRUAL: A total of 15 patients will be accrued for this study.