Safety and Immune Response of Different Pediatric Combination Vaccines.

Inclusion Criteria: * Aged ≥ 42 days and ≤ 89 days on the day of inclusion * Born at full term of pregnancy (≥ 36 weeks) * Informed consent form signed by the parent(s) or other legally authorized representative(s) before the 1st study related procedure * Vaccination with a hepatitis B vaccine at least 30 days before inclusion * Able to attend all scheduled visits and to comply with all trial procedures(i.e., access to a phone) * Provide blood sample prior to Dose 1 * Parent or legal representative willing to take rectal temperatures after each vaccination. Exclusion Criteria: * Participation in another clinical trial in the 4 weeks preceding the (first)trial vaccination * Planned participation in another clinical trial during the present trial period * Personal or immediate family history of congenital or acquired immunodeficiency, immunosuppressive therapy such as long-term systemic corticosteroids therapy * Known or suspected systemic hypersensitivity to any of the vaccine components or history of a life-threatening reaction to a vaccine containing the same substances as the trial vaccine(s) * Chronic illness that could interfere with trial conduct or completion * Received blood or blood-derived products since birth * Any vaccination in the 2 weeks preceding the first trial vaccination or planned in the 4 weeks after any trial vaccination. Flu vaccine could be administered only 2 weeks after any trial vaccination * Previous vaccination with any acellular pertussis- (DTaP) or whole cell pertussis- (DTwP) based combination vaccines, Haemophilus influenzae type b (Hib)-conjugate, poliovirus, or pneumococcal conjugate vaccines * Coagulation disorder contraindicating intramuscular (IM) vaccination * Clinically significant findings on review of systems (determined by investigator or sub-investigator to be sufficient for exclusion) * Developmental delay or neurological disorder * Any condition which, in the opinion of the investigator, would interfere with the evaluation of the vaccine or pose a health risk to the subject.