Broccoli Sprout Extract in Preventing Lung Cancer in Smokers

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins70 enrolled

Overview

RATIONALE: Chemoprevention is the use of certain drugs or substances to keep cancer from forming, growing, or coming back. The use of broccoli sprout extract may prevent lung cancer. PURPOSE: This clinical trial is studying how well broccoli sprout extract works in preventing lung cancer in smokers.

OBJECTIVES: Primary * Evaluate the effect of broccoli sprout extract on levels of DNA adducts in participants who smoke. * Determine the effectiveness of broccoli sprout extract in reducing tobacco-carcinogen induced DNA adducts in these participants. Secondary * Determine the effects of broccoli sprout extract on markers of the Nrf2 pathway in these participants. * Determine the effectiveness of broccoli sprout extract, in increasing the activity of the Nrf2 pathway, in these participants. * Evaluate the feasibility of using lymphocytes and buccal cells to monitor DNA adducts and changes in the Nrf2 pathway in these participants. OUTLINE: Participants are stratified according to GST genotypic polymorphism (M1 vs T1). Participants receive oral broccoli sprout extract daily for 3 weeks. Participants keep a daily diary of their eating and smoking habits for 3 weeks before, during, and for 3 weeks after study treatment. They must continue to smoke during the study, but are encouraged to quit after completing the study treatment. PROJECTED ACCRUAL: A total of 70 participants will be accrued for this study.

Study Type

INTERVENTIONAL

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Lung Cancer

Interventions

broccoli sprout extractDIETARY_SUPPLEMENT

complementary or alternative medicine procedurePROCEDURE

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

DISEASE CHARACTERISTICS: * Current smoker with ≥ 30 pack-year history of smoking PATIENT CHARACTERISTICS: Performance status * ECOG 0-2 Life expectancy * Not specified Hematopoietic * WBC \> 4,000/mm\^3 * Platelet count \> 100,000/mm\^3 Hepatic * Bilirubin ≤ 1.5 mg/dL Renal * Creatinine ≤ 1.5 mg/dL Other * Not pregnant or nursing * Negative pregnancy test * Fertile participants must use effective contraception * No other medical condition that would preclude study treatment or compliance * No gastrointestinal condition that would affect absorption, preclude taking oral medication, or necessitate IV alimentation PRIOR CONCURRENT THERAPY: Surgery * No prior surgery affecting absorption Other * More than 6 weeks since prior vitamins, herbal supplements, non-steroidal anti-inflammatory drugs, or antibiotics * No concurrent dietary intake of cruciferous vegetables

Locations (1)

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Baltimore, Maryland, United States

Data from ClinicalTrials.gov

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