Study With Rupatadine in Mosquito-Bite Allergic Adult Subjects

J. Uriach and Company30 enrolled

Overview

The study will find out how effective rupatadine is in the treatment of mosquito bite symptoms in adult patients allergic to mosquito bites.

Mosquito-bite symptoms include wheals and pruritic bite papules. Oral antihistamines have shown to decrease whealing ang accompanying pruritus in placebo-controlled trials. Subjects will be treated for 4 days, and exposed to experimental mosquito bite at day 3.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Allergy

Interventions

RupatadineDRUG

PlaceboDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Recent history of suffering from mosquito-bite reactions. * At least 5 mm diameter mosquito-bite wheal from Aedes aegypti laboratory mosquitoes Exclusion Criteria: * Pregnancy or lactating females * Oral antihistamines, corticosteroids or non-steroid anti-inflammatory drugs (NSAID) use within two weeks before the study. * Severe or moderate systemic illness * Allergy to rupatadine or other antihistamines * Anaphylaxis from mosquito bites

Locations (2)

Ulappatorin Lääkäriasema

Espoo, Finland

Koskiklinikka, Tampere Lääkärikeskus

Tampere, Finland

Outcomes

Primary Outcomes

Bite lesion size (squared mm)

Secondary Outcomes

Pruritus on a Visual Analog Scale

Central Contacts

Timo Reunala, Prof.

CONTACT

(+358) 331165167 timo.reunala@uta.fi

Data from ClinicalTrials.gov

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