Two-year multicentre randomized controlled parallel trial to compare intentional delivery and conservative management in pregnant women with preterm and prelabour rupture of membranes between 32 and 35 weeks. The purpose of this study is to determine whether intentional delivery of women with PPROM between 32 and 35 week's gestation can decrease the overall neonatal morbidity associated with PPROM-related complications without increasing the morbidity associated with a shortened pregnancy.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
152
Induction of delivery
Foothills Hospital
Calgary, Alberta, Canada
Royal Alexandra Hospital
Edmonton, Alberta, Canada
Grey Nuns Community Hospital
Edmonton, Alberta, Canada
Length of Stay in hospital
Time frame: time between birth and readiness for discharge
MAIN Score (Morbidity Assessment Index for Newborns)
Time frame: From birth to discharge
Early Onset Neonatal Sepsis
Time frame: from birth to discharge
Clinical and Histological Chorioamnionitis
Time frame: from birth to discharge
Antepartum Length of stay
Time frame: From diagnosis to delivery
C-Section
Time frame: delivery
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Caritas - Misericordia Hospital
Edmonton, Alberta, Canada
BC Women's Hospital and Health Centre
Vancouver, British Columbia, Canada
St. Boniface General Hospital
Winnipeg, Manitoba, Canada
Women's Hospital
Winnipeg, Manitoba, Canada
Saint-Joseph Health Care
London, Ontario, Canada
Sainte-Justine Hospital
Montreal, Quebec, Canada
Laval University Hospital
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...and 1 more locations