Aspirin Resistance Following Coronary Bypass Surgery

Sheba Medical Center

Overview

Aspirin was proved to be the drug preventing vein grafts from closure and improving clinical outcome after coronary artery bypass surgery. It appears to be effective when being prescribed as early as first 48 hr. after the operation without increasing the incidence of bleeding complications. the exact effective dose is not known.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Conditions

Ischemic Heart Disease

Interventions

Coronary artery bypass surgeryPROCEDURE

Eligibility

Sex: ALLMin age: 30 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients undergoing Coronary artery bypass surgery * Patients who signed Informed Consent Form Exclusion Criteria: * Concomitant valve surgery or carotid surgery or off-pump surgery * Need for anticoagulation therapy for any reason * Another antiplatelet medications at least 7 days prior to surgery * Contra-indication for aspirin treatment * Thrombocytopenia / thrombocytopathia * NSAIDs treatment for chronic medical conditions * Reluctance to participate in the study

Locations (1)

Sheba Medical Center

Ramat Gan, Israel

Outcomes

Primary Outcomes

Ventilation

Inotropic support

Mortality

Perioperative MI

Perioperative stroke

Bleeding / reopen / transfusion

Dysrhythmias

Secondary Outcomes

ICU stay

In-hospital stay

Non-fatal cardiac events - MI, recurrence of angina, dysrhythmias

Need for repeat revascularization

Data from ClinicalTrials.gov

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