Kinetic of Immune Memory Response After Re-Vaccination With Meningococcal Vaccine

Phase 4UnknownNCT00262015

Chiron Corporation264 enrolled

Overview

The purpose of this study is to determine when a memory immune response after re-vaccination with Meningococcal C conjugate vaccine (Menjugate) or challenge with Meningococcal A/C polysaccharide vaccine can be observed, after initial vaccination with Meningococcal C conjugate vaccine during the UK immunization campaign

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

264

Conditions

Meningococcal Disease; Meningococcal Meningitis

Interventions

· Meningococcal C conjugate vaccine; Meningococcal A/C Polysaccharide vaccine (partial dose)BIOLOGICAL

Eligibility

Sex: ALLMin age: 13 YearsMax age: 15 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy adolescents between and including 13-15 years of age, who provide written informed consent and who received one immunization with Chiron Meningococcal C Conjugate vaccine (Menjugate) during the UK immunization campaign and for which documentation can be provided. Exclusion Criteria: * Subjects with a previous or suspected disease caused by N. meningitidis; or previous immunization with a meningococcal vaccine or vaccine containing meningococcal antigen(s); Any serious acute, chronic or progressive disease

Locations (1)

University of Oxford, The Oxford Vaccine Group

Oxford, United Kingdom

Outcomes

Primary Outcomes

To measure immunological memory response to N. meningitidis serogroup C after those who received a partial dose of Meningococcal A/C Polysaccharide vaccine and in subjects who received a dose of Chiron Meningococcal C conjugate vaccine.

Secondary Outcomes

To assess the immunological response to N. meningitidis serogroup C in those challenged with meningococcal A/C polysaccharide vaccine and in those who received a dose of Chiron Meningococcal C conjugate vaccine.

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.