Elimination of Protein-bound Uremic Retention Solutes by Prometheus Artificial Hepatic System Versus Conventional Dialysis

University Hospital, Ghent

Overview

Comparison of the efficacy of dialysis by conventional dialysis versus Prometheus artificial hepatic system

After inclusion, patients will be dialysed with low-flux artificial kidneys. 1 week of dialysis exists of 3 days of dialysis. In week 4, day 2, patients will be treated once with the Prometheus artificial hepatic system or with high-flux dialysis. The other days low-flux kidneys will be used. Week 5 and 6 are a wash-out period. Week 7 is identical to week 4 but the other system than in week 4 is used. Blood samples are taken at regular moments in week 3, week 4 (day 2) and week 7 (day 2).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Conditions

Renal Failure, Chronic

Interventions

Dialysis with different artificial devicesDEVICE

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Stable patients * At least 3 months on dialysis * Arterio-venous fistula Exclusion Criteria: * Diabetic patients * Malignancies * Acute illnesses

Locations (1)

University Hospital Ghent

Ghent, Belgium

Outcomes

Primary Outcomes

Determination of the concentration of protein-bound toxins after treatment with different artificial devices

Secondary Outcomes

Determination of the kinetics of protein-bound toxins after treatment with different artificial devices

Data from ClinicalTrials.gov

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