Comparison of Automatic CPAP to Fixed CPAP for OSAS Following a Prediction Formula

University Hospital, Ghent45 enrolled

Overview

Comparison of automatic CPAP with fixed CPAP in patients with OSAS

The polysomnography is divided into two parts, randomly assigned: * in one part, the patient uses the automatic CPAP device in titration mode * in the other part, the patient uses the CPAP device, in fixed mode according to the prediction formula

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Obstructive Sleep Apnea Syndrome

Interventions

Comparison of automatic CPAP versus fixed CPAPDEVICE

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with proven Obstructive Sleep Apnea Syndrome * Apnea-hypopnea-index \> 20/h * Awaking index \> 30/h Exclusion Criteria: * Severe nasal obstruction * Hypoventilation * Excessive sleep fragmentation caused by non-respiratory factors * COPD (FEV1/FVC \< 65%) * CPAP compliance \< 3h per night * Insufficient sleep time (\< 2h TST) during one of both parts of the split night CPAP-titration * Patients needing \> 16 mbar CPAP pressures

Locations (1)

University Hospital Ghent

Ghent, Belgium

Outcomes

Primary Outcomes

Respiratory control expressed by residual number of obstructive and central apneas, hypopneas and snoring

Arousal index

Pressure profile Auto-CPAP (P50, P95 en Pmax)

All outcomes are measured during polysomnography

Secondary Outcomes

Pressure adaptation during polysomnography according to body position and sleep stage, pressure variability

Measurements of comfort, subjective evaluation by the patient by questionnaires immediately after polysomnography

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.