Comparison of the Efficacy and Safety of Ivermectin to Permethrin

University Ghent160 enrolled

Overview

Comparison of the efficacy and safety of a single administration of ivermectin to a single administration of permethrin for the treatment of scabies

Administration of ivermectin or permethrin on day0 Clinical examination and pictures on day0, day14 and day28 Blood sample on day0 VAS for pruritus, DLQI and SF-36 on day0, day14 and day28

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

160

Conditions

Scabies

Interventions

Administration of ivermectin or permethrinDRUG

Eligibility

Sex: ALLMin age: 5 Years

Medical Language ↔ Plain English

Inclusion Criteria: At least one of the following inclusion criteria: * Scabies tunnels * Positive microscopic examination (acarids, faeces or ova) At least two of the three following inclusion criteria: * Non-specific injuries with a typical distribution pattern * Serious itching which increases during the night * Family or contacts with similar complaints Exclusion Criteria: * Treatment for scabies \< 4 weeks ago * Treatment with corticoids \< 1 week ago * Pregnancy * Breast-feeding * HIV * Serious immunodepressive patients * Sensitivity or allergy to one of the components of the study medication * Damage of the central nerve system

Locations (1)

University Hospital Ghent

Ghent, Belgium

Outcomes

Primary Outcomes

Clinical healing of the skin injuries

Time frame: on day28

Secondary Outcomes

Decrease of itching

Time frame: on day28

Amelioration of the life quality

Time frame: on day28

Number and gravity of adverse events

Data from ClinicalTrials.gov

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