Effect of BNP (Brain Natriuretic Peptides) on Endothelial Dysfunction Induced by Coronary Angioplasty

The Baruch Padeh Medical Center, Poriya500 enrolled

Overview

Patients receiving BNP or nitroglycerin (IV) during the angioplasty procedure. 24 h after the procedure, vascular reactivity will be re-examined using the brachial artery flow-mediated dilatation study. Blood assays for ET-1, pro-BNP, and various inflammatory markers will be checked before and 24 h after the procedure. It is our hypothesis that endothelial function will be better in the BNP treated patients compared to the NTG treated patients

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

DOUBLE

Enrollment

500

Conditions

Coronary Artery Disease

Interventions

Nesiritide,DRUG

PCI

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria:coronary artery disease - Exclusion Criteria:CHF and/or reduced LV function, or renal failure with Creatinine \>2mg% \-

Locations (1)

The Baruch Pade medical center, Poriya

Tiberias, Israel

RECRUITING

Outcomes

Primary Outcomes

FMD

Time frame: 3 years

Central Contacts

Yonathan Hasin, prof.

CONTACT

97246652649 yhasin@poria.health.gov.il

Diab gahnim, Dr

CONTACT

Data from ClinicalTrials.gov

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