Pathophysiological Mechanisms of Hepatopulmonary Influence in the Fontan Circulation

University Hospital, Ghent40 enrolled

Overview

Randomisation between postoperative administration of an ACE-inhibitor or not.

Children that are undergoing elective surgery for the creation of a Fontan circulation will be randomised to postoperative administration of an ACE-inhibitor or not. Determination of aldosteron, renine and ADH in serum preoperatively and 1h, 12h and 5 days postoperatively.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Children With a Univentricular Heart Undergoing Surgery for Creation of a Fontan Circulation

Interventions

Administration of an ACE-inhibitor or notDRUG

Eligibility

Sex: ALLMin age: 1 MonthMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * All consecutive children with a univentricular heart disease undergoing elective surgery for creation of a Fontan circulation * Parents have agreed with the study after informed consent Exclusion Criteria: * Urgent / Emergent surgery * Preoperative use of an ACE-inhibitor

Locations (1)

University Hospital Ghent

Ghent, Belgium

Outcomes

Primary Outcomes

Duration of the pleural drainage in the first two postoperative weeks

Data from ClinicalTrials.gov

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