Metabolomic Analysis of Lung Cancer

University of Louisville249 enrolled

Overview

The purpose of this study is to learn more about the metabolic properties of lung cancer cells.

It has long been known that cancer cells absorb and break down substances in the body differently than healthy, non-cancer cells. This process of absorbing and breaking down substances is known as metabolism and is increased in cancer cells. Recent research suggests that this increased metabolic activity makes it easier for cancer cells to multiply. The objective of the study is to characterize the metabolism of glucose by lung tumors by serum metabolite analysis, using a variant of glucose (sugar) which makes up 1% of glucose in nature.

Study Type

OBSERVATIONAL

Enrollment

249

Conditions

Carcinoma, Non-Small Cell Lung Carcinoma, Small Cell Lung

Interventions

13-C-glucoseOTHER

10 grams of 13-C-glucose intravenously, as a 30-minute "piggyback" infusion, 2 to 6 hours prior to scheduled surgical resection of primary lung cancer.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Lung Cancer Patients (Groups 1 \& 2) Inclusion Criteria: * patients with suspected, clinically diagnosed, or histologically diagnosed lung cancer. Occasionally, other cancers (including metastatic cancers to the lung) may be resected for the study as negative controls for NSCLC, as warranted by the particulars of the case. * patients must have general medical conditions to allow them to undergo surgical resection of their primary tumor Exclusion Criteria: * history of diabetes for the experimental group (surgery + glucose); patients with a history of diabetes are allowed in the control group (surgery/no glucose) * known hepatitis C or HIV (AIDS) Healthy Subjects (Group 3) Inclusion Criteria: * at least 30 years of age * preferably be fasting for 12 hours (minimum 8 hours) prior to enrollment Exclusion Criteria: * prior history of diagnosed lung cancer * known hepatitis C or HIV (AIDS)

Locations (1)

James Graham Brown Cancer Center, University of Louisville

Louisville, Kentucky, United States

Outcomes

Primary Outcomes

metabolic profiles of cancerous vs. healthy lung tissue

Time frame: after 13-C-glucose infusion

Secondary Outcomes

glycolytic metabolism in plasma

Time frame: before and after 13-C-glucose infusion

metabolic markers in urine

Time frame: collected during surgery

metabolic markers in serum

Time frame: before and after 13-C-glucose infusion

metabolic markers in bronchoalveolar fluid

Time frame: during diagnostic bronchoscopy or during surgery

metabolic markers in expired breath

Time frame: during surgery

Data from ClinicalTrials.gov

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