A Study of ADH300004 in Surgically Resected Primary or Metastatic Colorectal Cancer and Liver Biopsy, or Planned Hepatic Resection

Inclusion Criteria: * Signed written informed consent * \> or = 19 years of age * Patients with histologically confirmed: * primary or metastatic (known or suspected) colorectal carcinoma requiring planned surgical resection with hepatic biopsy and systemic chemotherapy , or * primary or metastatic neoplastic disease within the liver from any origin requiring planned surgical resection and systemic chemotherapy * Adequate performance status and organ function, as evidenced by hematological and biochemical blood testing Exclusion Criteria: * Lack of known or suspected metastatic disease in the liver * Known DPD deficiency * Severe infection * Inability to take oral medication * The need for treatment with any fluoropyrimidine within 8 weeks of any ADH300004 dose * Stroke, major surgery, or other major tissue injury within 30 days before study entry