The Prevalence and Clinical Manifestations of Human Metapneumovirus Among Children With Bronchiolitis.

HaEmek Medical Center, Israel200 enrolled

Overview

Sputum specimens will be obtained from children \< 2 years of age and processed by different mode for the HMPV, RSV, Pertussis, Influenza A, B, Parainfluenza 1,2,3, Adenovirus. Clinical and epidemiological data will also be obtained.

The purpose of the study is to asses the various pathogens of bronchiolitis in children and its' clinical manifestations. Prospective study in 3 Medical centers in Northern Israel. Included will be about 200 infants and children \< 2 years hospitalized with bronchiolitis. From each child sputum specimen will be obtained and processed for HUMP - PCR, Pertussis - PCR, RSV - ELISA, DFA, PCR, Influenza A, B, Parainfluenza 1,2,3 - DFA, PCR, Adenovirus - DFA. Epidemiological data will be obtained for every child by structured questioner. Clinical data will be daily obtained by scoring system.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Respiratory Tract Infection Children

Eligibility

Sex: ALLMin age: 1 DayMax age: 2 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria:Age 0-24 months, hospitalized children, - Exclusion Criteria:Previous hospitalization, previous RSV immunization, immunocompromised patient, previous inclusion in this study, inclusion in another study. \-

Locations (3)

Pediatric department A, HaEmek Medical Center

Afula, Israel

Maier Hospital

Haifa, Israel

Pediatric Depart ment , Bnai Zion Hospital

Haifa, Israel

Data from ClinicalTrials.gov

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