Phase III Study of Topical Gel for Treatment and Prevention of Raynaud's Phenomenon

Inclusion Criteria: * Clinical diagnosis of Raynaud's phenomenon * 2 or more Raynaud's events on a typical winter day * Agree to discontinue current treatments for Raynaud's * Negative pregnancy test and agree to use effective contraception during study Exclusion Criteria: * Current use of nitrate medications or medications known to interact with nitroglycerin * Patients who currently use medications, like calcium channel blockers, that might interfere with study medication * Patients with a known allergy to nitroglycerin or common topical ingredients * Patients with a history of migraine headaches * Patients with a history of unstable medical problems * Patients with cognitive or language difficulties that would impair completion of assessment instruments * Patients with lab screening values more than 20% outside normal range * Patients with non-epithelialized skin lesions, in the area where the gel is to be applied, at the time of screening * Pregnant or nursing women * Women of child-bearing potential who are unwilling to comply with the contraceptive requirements