A Clinical Trial Comparing Torcetrapib/Atorvastatin To Simvastatin In Subjects With High Cholesterol (A5091031).

Phase 3TerminatedNCT00267280

Pfizer640 enrolled

Overview

The Torcetrapib project was terminated on December 2, 2006 due to safety findings. Cholesterol levels will be measured over six weeks in subjects being treated with two different kinds of cholesterol medications to see how the different treatments compare to one another.

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Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

640

Conditions

Hyperlipidemia Dyslipidemia Hypercholesterolemia

Interventions

torcetrapib/atorvastatinDRUG

simvastatinDRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * eligible for statin treatment for LDL cholesterol by NCEP guidelines Exclusion Criteria: * Women who are pregnant or lactating, or planning to become pregnant. * Subjects taking any drugs known to be associated with an increased risk of myositis in combination with HMG-CoA reductase inhibitors. * Subjects with significant liver or kidney disease or significant heart failure.

Locations (51)

Outcomes

Primary Outcomes

Percent change in LDL-C and HDL-C from baseline, after six weeks of treatment.

Secondary Outcomes

Changes in other lipid parameters and other biomarkers.

Data from ClinicalTrials.gov

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Pfizer Investigational Site

Birmingham, Alabama, United States

Pfizer Investigational Site

Mesa, Arizona, United States

Pfizer Investigational Site

Alhambra, California, United States

Pfizer Investigational Site

Inglewood, California, United States

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Los Angeles, California, United States

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Santa Ana, California, United States

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Wilmington, Delaware, United States

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Fort Lauderdale, Florida, United States

Pfizer Investigational Site

Hollywood, Florida, United States

Pfizer Investigational Site

Jacksonville, Florida, United States

...and 41 more locations