Objectives To evaluate the effect of increased vitamin D intake on vitamin D status, bone mass and bone turnover in young girls aged 12-13. More specifically the effects on the following parameters will be assessed: * Vitamin D metabolites. * Parathyroid hormone. * Bone turnover. * Bone mineral accretion. * Serum calcium and phosphate. * Renal handling of calcium and phosphate.
This work package will consist of a randomised double blind one-year vitamin D supplementation study. Primary effect parameter is change in bone mineral content and therefore study duration will be one year. A total of 225 subjects, 75 in each of the three groups: one control and two intervention groups, will be included Two dosages of supplementation will be used: 5 µg per day and 10 µg per day.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
225
Department of Human Nutrition, The Royal Veterinary and Agricultural University
Frederiksberg, Denmark
Vitamin D level (status) measured as s-25 hydroxy vitamin D at baseline, after half a year and one year.
Bone accretion measured by DXA. Measurement at baseline and after one year.
Bone turnover measured at baseline, half a year and one year
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