Enhancement of Postocclusive Reactive Hyperaemia by Dipyridamole

Radboud University Medical Center12 enrolled

Overview

The purpose of this study is to determine whether dipyridamole enhances postocclusive reactive hyperaemia by increasing extracellular adenosine concentrations during ischemia and reperfusion. Furthermore we hypothesize that dipyridamole augments postocclusive reactive hyperaemia by increasing adenosine receptor stimulation.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Hyperemia Hypoxia

Interventions

dipyridamoleDRUG

caffeineDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy volunteers between 18 and 50 years Exclusion Criteria: * none specified

Locations (1)

Radboud university Nijmegen Medical Centre

Nijmegen, Gelderland, Netherlands

Outcomes

Primary Outcomes

forearm blood flow

Data from ClinicalTrials.gov

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