Capecitabine Associated With Weekly Paclitaxel in Metastatic Breast Cancer.

Inclusion Criteria: * Femal patient aged \> 18 years * Histologically proven breast adenocarcinoma * HER2 negative receptors * previously received first or second line chemotherapy for metastatic disease * previously treated with anthracycline and/or docetaxel in adjuvant and/or as first or second line therapy * presence of one or several evaluable metastatic lesion(s) * presence of at least one target lesion not previously irradiated * previously treated with hormonotherapy in adjuvant or in metastatic line (treatment will be ceased upon patient registration in the study) * ECOG Performance status \< 2 * adequate biological values * patient who has clearly given her consent by signing on informed consent form prior to participation Exclusion Criteria: * patient previously treated with paclitaxel or capecitabine for metastatic breast cancer * patient with only local metastatic disease (with the exception of axillary lymph nodes) * active symptomatic brain metastasis * patient with an history of significant cardiovascular impairment (congestive heart failure\> NYHA grade II, unstable angina or myocardial infraction within the past six months or serious cardiac arrhythmia) * peripheric neuropathy grade ≥ 2 * history of another malignancy within past 5 years that could confound diagnosis or staging of breast cancer (with the exception of in situ cacinoma of the cervix or adequately treated basel cell carcinoma of the skin) * patient with any medical or psychiatric condition that, in the opinion of the Principal Investigator, would preclude her from participating in this study * patient with a known allergy to one or several of the study compounds * patients who may not be regularly available due to geographical, social or family reasons * history of renal, hepatic or metabolic pathology that could preclude with metabolism or elimination of the study product * deficiencies of the upper intestinal tract, malabsorption syndrome * patient who is pregnant, breast-feeding or using inadequate contraception