Radiofrequency Catheter Ablation for Chronic Atrial Fibrillation

University of Michigan140 enrolled

Overview

The purpose of this study is to determine the long-term efficacy of radiofrequency catheter ablation in patients with chronic atrial fibrillation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

140

Conditions

Atrial Fibrillation

Interventions

Radiofrequency catheter ablationPROCEDURE

Amiodarone and cardioversionDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Chronic atrial fibrillation Exclusion Criteria: * Left atrial diameter \>55 mm * Left ventricular ejection fraction \<0.30 * Contraindication to amiodarone therapy or anticoagulation with warfarin * Presence of a mechanical prosthetic valve * History of a cerebrovascular accident * Presence of left atrial thrombus on TEE * Prior attempt at catheter or surgical ablation for atrial fibrillation

Locations (2)

University of Michigan Health System

Ann Arbor, Michigan, United States

San Raffaele Hospital

Milan, Italy

Outcomes

Primary Outcomes

Freedom from atrial fibrillation and atrial flutter in the absence of antiarrhythmic drug therapy at 1 year.

Secondary Outcomes

incidence of complications

changes in left atrial diameter

changes in left ventricular ejection fraction

changes in symptom severity

Data from ClinicalTrials.gov

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