Lumigan Versus Cosopt

Pharmaceutical Research Network34 enrolled

Overview

To compare the intraocular pressure effect and safety of the dorzolamide/timolol fixed combination given twice daily versus bimatoprost given once every evening in patients with open-angle glaucoma in patients insufficiently controlled on latanoprost monotherapy

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Open-Angle Glaucoma

Interventions

bimatoprost 0.03%DRUG

dorzolamide 2%/timolol maleate 0.5% fixed combinationDRUG

placeboDRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * adults with a diagnosis of bilateral open-angle glaucoma including: primary, pigment dispersion or exfoliation in both eyes * on no therapy the intraocular pressure should be 22-29 mm Hg inclusive at the 8:00 AM measurement * visual acuity should be 20/200 or better in each eye Exclusion Criteria: * historical failure to respond to topical beta-blockers in a clinically meaningful manner * any contraindication to study medications * any anticipated change, or modification in the 6 weeks prior to Visit 1, in systemic hypertensive therapy during the trial

Locations (3)

Taustine Eye Center

Louisville, Kentucky, United States

Glaucoma Consultants & Center for Eye Research, PA

Mt. Pleasant, South Carolina, United States

Houston Eye Associates

Houston, Texas, United States

Data from ClinicalTrials.gov

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