Cosopt Versus Xalacom

Pharmaceutical Research Network33 enrolled

Overview

To compare the intraocular pressure efficacy and safety of the DTFC given twice daily versus the LTFC given once every morning following a run-in period with timolol maleate given twice daily.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Open-Angle Glaucoma Ocular Hypertension

Interventions

dorzolamide 2%/timolol maleate 0.5% fixed combinationDRUG

latanoprost 0.005%/timolol maleate 0.5% fixed combinationDRUG

timolol maleate 0.5%DRUG

placebo

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * adults with primary open-angle or pigment-dispersion glaucoma, or ocular hypertension * at baseline the intraocular pressure should be 20 to 32 mm Hg inclusive at 08:00 measurement (Visit 2) after dosing with timolol the evening before * the intraocular pressure should be 32 mm Hg or less at all the time points in both eyes at Visit 2 * visual acuity should be 6/60 or better in the study eye(s) Exclusion Criteria: * any anticipated change in systemic hypotensive therapy during the trial * use of any corticosteroids by any route for more than two weeks during the study * contraindications to study medicines

Locations (2)

Lawson Health Research Insitute

London, Ontario, Canada

University Eye Clinic

Ljubljana, Slovenia

Data from ClinicalTrials.gov

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