A Study Comparing Outcomes of Kidney Transplants in Patients on Steroids Versus Those Who Discontinue Steroids

Inclusion Criteria: * Patients undergoing a single renal transplant from deceased or living donor * Adults 18 years and older * First or second renal transplant * Capable of understanding the purposes of the study, has given written informed consent, and agrees to comply with the study requirements * Women of child bearing age should have a negative serum pregnancy test Exclusion Criteria: * Greater than 2 renal transplants * Age \< 18 years * Patients receiving immunosuppressive therapy within the preceding 28 days for first transplant and 3 months for the second transplant * Cold ischemia time \> 30 hours * History of malignancy in the last 5 years except successfully treated localized non-melanoma skin cancer * HIV, hepatitis B virus (HBV), or hepatitis C virus (HCV) positive serology * Loss of previous transplant in \< 1 year * History of non-compliance * Any form of substance abuse, psychiatric disorder or condition which, in the opinion of the investigator, may impair communication with the investigator or compliance with study procedures * Multiple organ transplant * History of chronic steroid use except for inhaled steroids for asthma * Pregnant or lactating females * Women of childbearing potential not willing to use a reliable form of contraception. * Patients with severe medical condition(s) that, in the view of the investigator, prohibits participation in the study * Known sensitivity to study drugs or class of study drugs * Use of any investigational agent in the last 30 days