Prevention of High Altitude Pulmonary Edema

University of Zurich30 enrolled

Overview

A double-blind placebo controlled study * To compare the effect of tadalafil and dexamethasone versus placebo on Ppa and pulmonary edema formation in subjects susceptible to HAPE. * To investigate the effect of dexamethasone on alveolar fluid clearance, as assessed by measurement of the nasal potential difference, and prevention of HAPE. * To investigate the effect of the tadalafil and dexamethasone versus placebo on the dynamic CBF autoregulation properties and on the development of AMS in HAPE susceptible subjects.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

High Altitude Pulmonary Edema

Interventions

dexamethasone 8 mg bidDRUG

tadalafil 10mg bidDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * At least one previous episode of high altitude pulmonary edema Exclusion Criteria: * pulmonary arterial hypertension * congenital heart disease * any chronic lung disease

Outcomes

Primary Outcomes

prevention of high altitude pulmonary edema

Secondary Outcomes

incidence of acute mountain sickness

Data from ClinicalTrials.gov

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