The Comparison of Tacrolimus and Sirolimus Immunosuppression Based Drug Regimens in Kidney Transplant Recipients

Inclusion Criteria: * Living and deceased donor kidney transplant recipients at the Mayo Clinic, Rochester, Minnesota Exclusion Criteria: * Patients with type 1 diabetes less than 50 years of age who receive a living donor kidney transplant followed by a pancreas transplant * Pediatric patients (\<18 years of age) * Multi-organ transplants (e.g., kidney-pancreas, kidney-liver) * ABO-incompatible or positive crossmatch recipients (ABO incompatibility is an immune system reaction that occurs when blood from two different and incompatible blood types are mixed together.) * Patients with severe hyperlipidemia (serum cholesterol \>350 mg/dl or serum triglycerides \>500 mg/dl * Patients with severe leukopenia (White Blood Cell count \[WBC\]\<3000 10\^3/ml) * Patients unwilling to return to the transplant center for late follow-up visits * Body mass index (BMI) ≥ 32 with incisional problems post transplant (as determined by renal transplant surgeon