Use of MRI for Assessing Stomach Relaxation in Response to a Meal

Inclusion criteria for Dyspeptic patients (30 required) * One or more of eight postprandial dyspeptic symptoms i.e. fullness, bloating, epigastric discomfort, early satiety, nausea, vomiting, belching, pain for a minimum of 3 months, OR * Patients fulfilling the ROME-II criteria for functional dyspepsia, * AND no symptom improvement after standard dose PPI treatment, * AND normal upper gastrointestinal endoscopy within six months prior to the study Inclusion Criteria for Healthy Controls (20 required) • Absence of current abdominal symptoms or depression Exclusion Criteria for all Participants * Known structural upper GI disorder (e.g. peptic ulcer disease, esophagitis, malignancy); * Abdominal surgery other than appendectomy, cholecystectomy, hysterectomy, tubal ligation, or inguinal hernia repair; * Medications that may alter gastrointestinal motility, e.g., serotoninergic agents, alpha adrenergic agonists, calcium channel or beta blockers; stable dose of thyroxine will be permitted; * Pregnant or breast-feeding females; * Known claustrophobia; * Any metal objects in the body (e.g. metal implants, pacemaker, AICD)