Treatment of Breast Pain Using A Medication (Diclofenac) Applied to the Skin

Inclusion criteria * Noncyclic mastalgia or surgical scar-related pain occurring at least 2 days per week and for which the patient desires treatment * Duration of pain \> 2 months (noncyclic mastalgia) or \> 4 months (surgical scar-related pain) * Age \> 18 years * Satisfactory breast examination and directed ultrasound at site of pain (all ages) within 12 months * Satisfactory mammogram (all women \> 30 years of age) within 12 months * Negative pregnancy test (all women who are premenopausal and have not had hysterectomy or tubal ligation) Exclusion criteria * Cyclic mastalgia (as defined above) * Duration of pain \> 2 months (noncyclic mastalgia) or \> 4 months (surgical scar-related pain) * Abnormal breast examination or imaging (abnormality at the site of pain or for which biopsy or surgical consultation is recommended) * Known pregnancy, lactation, positive pregnancy test, or anticipated pregnancy within 6 months * Asthma, that has been aggravated by oral nonsteroidal antiinflammatory agents * Allergy, to diclofenac or any nonsteroidal antiinflammatory agents * Rash or open lesions at the site on the breast where the topical agent would be applied * Incomplete or abnormal healing (surgical scar-related pain) * History of gastrointestinal ulceration, renal dysfunction (creatinine \> 1.5), hepatic disease (known liver disease or aspartate aminotransferase (AST) twice normal levels), congestive heart failure and uncontrolled hypertension (blood pressure \> 140/90)