Sorafenib may stop the growth of cancer cells by blocking blood flow to the cancer and by blocking some of the enzymes needed for cell growth. This phase II trial is studying how well sorafenib works in treating patients with chemosensitive recurrent aggressive non-Hodgkin's lymphoma
PRIMARY OBJECTIVES: I. Determine the overall response rate, including complete and partial responses, in patients with chemosensitive, relapsed, aggressive, non-Hodgkin's lymphoma treated with sorafenib. SECONDARY OBJECTIVES: I. Determine progression-free and overall survival of patients treated with this drug. II. Determine response duration in patients treated with this drug. OUTLINE: This is an open-label study. Patients receive oral sorafenib twice daily in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed periodically. PROJECTED ACCRUAL: A total of 33 patients will be accrued for this study.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
33
Given orally
Correlative studies
University of Maryland Greenebaum Cancer Center
Baltimore, Maryland, United States
Objective response rate (complete and partial response)
Will be calculated as the percent of evaluable patients whose best response is a CR or PR. The exact binomial method will be used to determine the confidence interval of response rate.
Time frame: Up to 2 years
Overall survival
The Kaplan-Meier product-limit method will be used in analysis of survival time.
Time frame: Up to 2 years
Time to disease progression
The Kaplan-Meier product-limit method will be used in analysis of time to disease progression.
Time frame: Up to 2 years
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