Clot Formation and Clot Stability in Patients With Severe Haemophilia A

University of Aarhus8 enrolled

Overview

In the present study we are examining the clot formation and clot stability in patients with severe haemophilia A after they receive recombinat factor VIII and after addition of tranexamic acid. Our hypothesis is that addition of tranexamic increases the clot stability. The perpective of the study is to document whether it is relevant to use traneksamic acid in surgery in patients with severe haemophilia A.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Hemophilia A

Interventions

ReFacto (Recombinant factor VIII) and Tranexamic acidDRUG

Eligibility

Sex: MALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Severe haemophilia A * Above 17 years old * Thrombocyt count above 100 x 109/l within the past two years Exclusion Criteria: * Received recombinant factor VIII with in the past 3 days * Inhibitor against recombinant factor VIII * HIV-positive * Ongoing treatment for hepatitis C * Known kidney disease * Allergy against Tranexamic acid * Not able to give informed consent

Locations (1)

Department of Clinical Biochemistry, Center for Haemophilia and Thrombosis

Aarhus, Denmark

Outcomes

Primary Outcomes

Clot stability

Secondary Outcomes

clot formation,thrombine generation

Data from ClinicalTrials.gov

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