Hypothesis: Computer controlled continuous positive airway pressure (autoCPAP) is equally effective in improving obstructive sleep apnea syndrome symptoms, breathing disturbances, objective vigilance, and it is cost-effective compared to conventional fixed continuous positive airway pressure.
1. To investigate whether computer controlled continuous positive airway pressure (autoCPAP) improves subjective sleepiness, quality of life, objective vigilance, and nocturnal respiration to a similar degree as conventional fixed continuous positive airway pressure in the initial phase of treatment and over the subsequent 2 years during home therapy 2. To investigate the cost of autoCPAP compared to fixed CPAP therapy
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
208
different CPAP mode
different CPAP mode
Pulmonary Division and Sleep Disorders Center, University Hospital of Zurich
Zurich, Switzerland
subjective sleepiness and other OSAS symptoms
Time frame: 3 months, 1 year, 2 years
quality of life
Time frame: 3 months, 1 year, 2 years
percentage of withdrawal and cross-over to other CPAP mode
Time frame: 3 months, 1 year, 2 years
objective vigilance
Time frame: 3 months, 1 year, 2 years
blood pressure
Time frame: 3 months, 1 year, 2 years
cost/utility ratios
Time frame: 3 months, 1 year, 2 years
major outcomes in subgroups of patients with severe and mild OSAS
Time frame: 3 months, 1 year, 2 years
circulating markers of inflammation and cardiovascular risk
Time frame: 3 months, 1 year, 2 years
side effects
Time frame: 3 months, 1 year, 2 years
nocturnal respiratory disturbances
Time frame: 3 months, 1 year, 2 years
treatment adherence
Time frame: 3 months, 1 year, 2 years
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.