A selection study in treatment naive HIV patients to compare the virologic success rate of once daily antiretroviral treatment regimens at the 48th week with Epzicom(lamivudine and abacavir) plus efavirenz and Epzicom plus ritonavir boosted atazanavir. The superior regimen will be hired to the comparative study to the current first line regimen (tenofovir plus lamivudine plus efavirenz)
A selection study in treatment naive HIV patients to compare the virologic success rate of once daily antiretroviral treatment regimens at the 48th week with Epzicom(lamivudine and abacavir) plus efavirenz and Epzicom plus ritonavir boosted atazanavir. The superior regimen will be hired to the comparative study to the current first line regimen (tenofovir plus lamivudine plus efavirenz) The primary endpoint is antiretroviral effect at the 48th week. The secondary endpoint is;1. Evaluation of immunological effect and safety in 48 weeks. 2.Evaluation of antiretroviral effect, immunological effect and safety in 49 to 96 weeks.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
71
Patients are treated with ritonavir 100mg boosted atazanavir 300mg along with Epzicom.
Patients are treated with efavirenz 300mg along with Epzicom.
International Medical Center of Japan
Shinjuku, Tokyo, Japan
Antiretroviral effect at the 48th week
Time frame: 48 weeks
1. Evaluation of immunological effect and safety in 48 weeks.
Time frame: 48 weeks
2.Evaluation of antiretroviral effect, immunological effect and safety in 49 to 96 weeks.
Time frame: 96 weeks
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