Urinary Aquaporin 2 Excretion After NSAID in Fasting Healthy Human

Regional Hospital Holstebro20 enrolled

Overview

We wanted to test the hypothesis that prostaglandin inhibition reduces the down regulation of u-AQP-2 induced by fasting

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

DOUBLE

Enrollment

Conditions

Healthy

Interventions

NSAIDDRUG

Eligibility

Min age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * (1) Genders; both mal and female * (2) Age; 18- 65 years old * (3) BMI; below 30 * (4) Females had to bee in oral contraceptive treatment Exclusion Criteria: * (1) Clinical signs or history of disease in the heart, lungs, kidneys or endocrine organs * (2) Abnormal laboratory test (blood haemoglobin, white cell count, platelets, plasma sodium, plasma potassium, plasma creatinine, plasma albumin, plasma bilirubin, plasma alanine aminotransferase, plasma cholesterol and blood glucose) * (3) Albuminuria or glucosuria * (4) Cancer * (5) Arterial hypertension * (6) Alcohol abuse * (7) Use of tobacco * (8) Medical treatment, except oral contraceptives * (9) Pregnancy or breast feeding * (10) Medicine abuse * (11) Donation of blood less than 1 month before the study.

Locations (1)

Department of Medicine, Holstebro Hospital

Holstebro, Denmark

Outcomes

Primary Outcomes

FeNa

U-AQP-2

Data from ClinicalTrials.gov

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