Allogeneic Hematopoietic Stem Cell Transplantation (NST) for Patients With Systemic Sclerosis

Patient Inclusion Criteria: 1. Age 18 to 55 years old 2. An established diagnosis of scleroderma (84) 3. Diffuse cutaneous scleroderma with involvement proximal to the elbow or knee and a Rodnan score (see Appendix III) of \> 14 (85) And one of the following: 1. DLCO \< 80% of predicted or decrease in lung function (TLC, DLCO or FEV1) of 10% or more over 12 months 2. Active alveolitis on bronchoalveolar lavage 3. Pulmonary fibrosis or alveolitis on CT scan or CXR 4. Elevated ESR greater than or equal to 25mm/hour confirmed on a second occasion at least two weeks apart without evidence of active infectious process. 5. Abnormal EKG (low QRS voltage, or ventricular hypertrophy) or left ventricle (LV) diastolic dysfunction (expressed by an inverted E/A ratio which represents early and late filling of the LV during atrial contraction) or LV wall thickness 6. Since pulmonary disease independent of skin score (NEJM, 2006, 345:25 2655-2709) carries a poor prognosis, patient may be enroled for only lung involvement defined as active alveolitis on BAL or ground-glass opacity on CT, a DLCO \< 80% predicted or decrease in lung function (TLC), DLCO, FVC) of 10% or more in last 12 months. Patient Exclusion Criteria: 1. Poor performance status (ECOG \> or =2) at the time of entry, unless due to disease. 2. Significant end organ damage such as: 1. LVEF \<40% or deterioration of LVEF during exercise test on MUGA or echocardiogram 2. Untreated life-threatening arrhythmia 3. Active ischemic heart disease or heart failure 4. DLCO less than 45% of predicted value, unless due to disease. 5. Pulmonary hypertension (estimated systolic pulmonary arterial pressure \>40 mmHg by Doppler echocardiography or measurement by pulmonary arterial catheter) 6. Serum creatinine \> 2.0 mg/dl 7. Liver cirrhosis, transaminases \>3x of normal limits or bilirubin \>2.0 unless due to Gilberts disease 3. HIV positive 4. Uncontrolled diabetes mellitus or any other illness that in the opinion of the investigators would jeopardize the ability of the patient to tolerate aggressive treatment 5. Prior history of malignancy except localized basal cell or squamous skin cancer. Other malignancies for which the patient is judged to be cured by local surgical therapy, such as (but not limited to) head and neck cancer, or stage I or II breast cancer will be considered on an individual basis. 6. Positive pregnancy test, inability or unable to pursue effective means of birth control, failure to willingly accept or comprehend irreversible sterility as a side effect of therapy 7. Psychiatric illness or mental deficiency making compliance with treatment or informed consent impossible 8. Inability to give informed consent 9. Age \<18 or \> 55 years old Donor Inclusion Criteria: 1. Donor must be a HLA identical sibling or HLA matched cord blood donor 2. If donor is HLA matched sibling, donor must be \> 18 years of age and less than 50 years old 3. If multiple HLA matched donors are available, preference will be given to same sex, same CMV status, or in the case of cord blood higher nucleated cell count 4. If donor is HLA matched cord blood, cord blood stem cells will be obtained from the New York Blood Center Cord Blood Registry (Tel 212-570-3230) which is an internationally recognized registry or, if a match is not available, from Stemcyte (626-821-9860) which is a commercial registry that specializes in minority donors. One unit of HLA matched cord blood unit will be infused on day zero Donor Exclusion Criteria: 1. Age \> 50 years old or \<18 years old 2. HIV positive 3. Active ischemic heart disease or heart failure 4. Acute or chronic active hepatitis 5. Uncontrolled diabetes mellitus or any other illness that in the opinion of the investigators would jeopardize the ability of the donor to tolerate stem cell collection 6. Prior history of malignancy except localized basal cell or squamous skin cancer. Other malignancies for which the patient is judged to be cured by local surgical therapy, such as (but not limited to) head and neck cancer, or stage I or II breast cancer will be considered on an individual basis. 7. Positive pregnancy test 8. Psychiatric illness or mental deficiency making compliance with treatment or informed consent impossible 9. Major hematological abnormalities such as platelet count less than 100,000/ul, ANC less than 1000/ul 10. If donor is sibling must collect a minimum of 2. 106CD34+ cells/kg to proceed to transplant 11. If donor is cord blood unit(s) then a minimum number of nucleated cells available must be more than 2 x 107 /kg. To achieve this number of nucleated cells, two units of HLA matched cord blood may be utilized. (Wagner JE Blood. 2005 Feb 1;105(3):1343-7)