Safety and Feasibility Study of Autologous Progenitor Cell Transplantation in Diabetic Neuropathy

Inclusion Criteria: * Patients with distal symmetrical diabetic neuropathy of the legs * Type 1 or Type 2 Diabetes * Stable Glucose control over last 3 months (Hba1c \<7.5) * Written informed consent Exclusion Criteria: * Patients with peripheral arterial disease (ABI \<0.9) * Neuropathy of other origin * Myopathy * Asymmetrical neuropathy * Active infection oder fever * Chronic inflammatory disease (z.B M. Crohn, Rheumatoid Arthritis) * HIV or hepatitis * Neoplastic disease without complete remission within last 5 y * Stroke or myocardial infarction within last 3 months * Renal failure (creatinine \> 2 mg/dl) * Liver disease (GOT \> 2 upper limit or spontaneous INR \> 1,5). * Anemia (hemoglobine \< 8.5 mg/dl) * Platelets \<100.000/µl * HbA1c \>7,5 % * Allergies to Aspirin, Clopidogrel, Heparin * Bleeding disorder * Surgery or trauma within the last 2 months * Pregnancy * Mental retardation * Participation in another study within 30 days