Decreased bone strength is a serious medical problem present in many women with Anorexia Nervosa, or disordered eating. Women with weaker bones are more likely to suffer broken bones than women with normal bone strength. We are investigating whether a hormone that is naturally produced by the human body, called growth hormone, can help strengthen the bones of women with this type of disordered eating.
* Twelve week study * Eight visits, six of which can be conducted at your home physician's office * Two bone density scans * Hormonal and nutritional evaluations
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
21
Dosage increased in steps for first four weeks. Self injection qd x 12 weeks
Administered as Arm 1, rHGH active Injection qd x 12 weeks Dosage increase over four weeks
Massachusettes General Hospital
Boston, Massachusetts, United States
Bone Metabolism
Change in the marker of bone formation, N-terminal pro peptide of type 1 procollagen (P1NP) levels, between baseline and 12 weeks
Time frame: Baseline, 12 weeks
IGF-1 Level
Change in IGF-1 level between baseline and 12 weeks
Time frame: Baseline, 12 Weeks
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