Ethnic Differences in the Inflammatory Response in Systemic Inflammation

Inclusion Criteria: * Signed informed consent obtained before any trial-related activities. (Trial activities are any procedure that would not have been performed during normal management of the subject). * Men aged \>18 and \<40 years * Normal findings in medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant * Normal laboratory values unless the investigator considers an abnormality to be clinically irrelevant Exclusion Criteria: * Treatment with an investigational drug within three weeks prior to this trial * Participation in an LPS trial within the last 6 weeks * Hereditary deficiency of protein C or S, or a mutation of FV (Leiden), or any other known abnormality affecting coagulation, fibrinolysis or platelet function * History of cardiovascular disease * Liver or kidney dysfunction * Regular use of medication or alcohol abuse * Use of any medication within three weeks prior to the first trial day * Symptoms of a clinically relevant illness in the 3 weeks before the first trial day * Excessive sporting activities * Weight over 95 kg