Peptic ulcer disease is the most common gastrointestinal disease. Antibiotic resistant Helicobacter pylori is a major problem worldwide. The gold standard for Helicobacter pylori eradication is composed of Proton-pump inhibitor/Ranitidine bismuth citrate + Amoxycillin + Metronidazole /Clarithromycin. In Thailand, clarithromycin resistant strains increased and led to treatment failure. Data on file at Rajavithi Hospital showed that metronidazole resistant H. pylori was about 50% and Clarithromycin resistant strains accounted for 8%. This molecular genetic study will be performed in patients presenting with dyspepsia, who had an indication for gastroscopic examination, to explore the incidence of antibiotic resistant Helicobacter pylori in Rajavithi Hospital, Thailand.
Genetic and Biomolecular factors determining clarithromycin resistance will be characterized.
Study Type
OBSERVATIONAL
Enrollment
200
gastroscopic examination for tissue biopsy and real time PCR for gene study
Rajavithi Hospital
Ratchathewi, Bangkok, Thailand
Incidence of H. pylori Clarithromycin resistance gene
Time frame: one year
Characteristic of H. pylori clarithromycin resistant gene mutation
Time frame: one year
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