Feasibility of Radiotherapy and Concomitant Gemcitabine and Oxaliplatin in Locally Advanced Pancreatic Cancer and Distal Cholangiocarcinoma

Inclusion Criteria: * Histologically proven and unresectable adenocarcinoma of the pancreas or cholangiocarcinoma with no evidence of metastatic disease * WHO performance status of 0 or 1 * Complete recovrey from surgery in case an enteric and/or biliary tract by-pass operation has been performed * Maximum delay after surgery: 8 weeks * No previous or co-existent malignant disease except non melanoma skin cancers and adequately treated cervic carcinoma in situ * Adequate bon marrow reserve * No previous chemotherapy or radiotherapy * Expected survival \> 6 months Exclusion Criteria: * Active infection * Metastatic disease * Inadequate liver function after derivative surgery * Inadequate renal function * Pregnancy, breast feeding * Use of any other investigational agent in the month before enrollment * Patients with grade 2 or more neuropathy