Effect of Cold Air Cooling on the Incidence of Post Inflammatory Hyperpigmentation Following Laser Treatment

Mahidol University20 enrolled

Overview

\- To investigate the benefit of epidermal cooling on the incidence of post inflammatory hyperpigmentation after laser irradiation

* 70% incidence of post inflammatory hyperpigmentation has been reported following a Q-switched nd:YAG laser treatment of acquired bilateral nevus of Ota-like macules. * We assumed that epidermal cooling may minimize the non-specific injury to the epidermis caused during laser irradiation, leading to the decreased incidence of post inflammatory hyperpigmentation.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Masking

DOUBLE

Enrollment

Conditions

Nevus Hyperpigmentation

Interventions

Cold air coolingDEVICE

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Subjects with acquired bilateral nevus of Ota-like macules. * At least 18 years old * No previous treatment on the condition for a minimum period of 1 month. Exclusion Criteria: * Subjects diagnosed of scleroderma, connective tissue disorders, hematologic disorders, hepatitis, infection, or uncontrolled DM * History of keloid and/or hypertrophic scar. * Currently on anti-coagulant

Locations (1)

Department of Dermatology, Siriraj Hospital, Mahidol University

Bangkok, Bangkok, Thailand

Outcomes

Primary Outcomes

Incidence of post inflammatory hyperpigmentation

Time frame: 2 weeks

Secondary Outcomes

Side effects of cold air cooling and clearing rate of pigmented lesion

Time frame: 12 weeks

Data from ClinicalTrials.gov

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