Immediate Radiotherapy or Observation After Surgery for Melanoma Involving Lymph Nodes

Inclusion Criteria: * Regional macroscopic nodal metastatic melanoma in one nodal basin region only which has been completely resected. * melanoma involving lymph nodes at high risk of local recurrence (details in protocol) * No evidence of metastases * No active major cancer within 5 years * Normal blood tests * WHO performance status of 0 or 1 * Radiotherapy must be able to be commenced within 12 weeks of lymphadenectomy * Patient must not be pregnant and if fertile must use a medically acceptable contraceptive throughout treatment * No major concurrent illnesses likely to cause death within 2 years * Written informed consent has been given Exclusion Criteria: * Evidence of active or previous local recurrence or in transit disease * Evidence of distant metastases on clinical or radiological investigation * Patients with prior cancers