Anticonvulsant Mood Stabilizers, Antipsychotic Drugs and the Insulin Resistance Syndrome

Inclusion criteria To be eligible, patients must : * Be male or female, age 18-65 * Be diagnosed with schizophrenia, schizoaffective disorder or bipolar disorder with psychotic features according to DSM-IV criteria * Be currently receiving antipsychotic drugs (clozapine, haloperidol, olanzapine, quetiapine, or risperidone) (APDs) alone, mood stabilizer(s) (MS) alone, or a combination of the two * Have a history of compliance with the above medication * Have presumptive IRS as indicated by a TG/HDL ratio \> 3.5 on current antipsychotic medication * Be Medicaid eligible or maintain insurance covering requested lab procedures * Be able to provide written informed consent Exclusion criteria A patient will be considered ineligible if he/she: * Has a diagnosis other than schizophrenia, schizoaffective disorder or bipolar disorder with psychotic features according to DSM-IV criteria. * Has a history of noncompliance with prescribed psychiatric medications * Has a TG/HDL ratio \< 3.5 on current medication * Is uninsured or is unable to self-pay potential costs of required lab procedures not covered by insurance. * Is unable to provide written informed consent. * (Females only) Is pregnant, lactating or plans to become pregnant during study participation Exclusion Criteria: \-