[S,S]-Reboxetine Dose-Range Finding Trial

Pfizer280 enrolled

Overview

The purpose of this study is to determine the effectiveness of different doses of \[S,S\]-Reboxetine in the treatment of chronic pain following a shingles infection

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

280

Conditions

Pain

Interventions

[S,S]-ReboxetineDRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients must have pain present for more than 3 months after the healing of shingles skin rash * Patients at screening must have a score \>/=40 mm on the pain visual analogue scale Exclusion Criteria: * Patients with significant renal and hepatic impairment * Patients with other severe pain, that may impair the self-assessment of the pain due to shingles * Patients with clinically abnormal electrocardiogram

Locations (79)

Outcomes

Primary Outcomes

The numerical pain intensity rating scale is used to assess pain and a change from baseline in pain score for week 14 will be calculated

Secondary Outcomes

- The mean endpoint (week 14) sleep interference score change from baseline - Analysis of the Medical Outcomes Study Sleep Scale - Analysis of the Patient Global Impression of Change - Analysis of the SF-36 Health Survey

Data from ClinicalTrials.gov

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Pfizer Investigational Site

Huntsville, Alabama, United States

Pfizer Investigational Site

Chandler, Arizona, United States

Pfizer Investigational Site

Mesa, Arizona, United States

Pfizer Investigational Site

Phoenix, Arizona, United States

Pfizer Investigational Site

Sun City, Arizona, United States

Pfizer Investigational Site

Tucson, Arizona, United States

Pfizer Investigational Site

Hot Springs, Arkansas, United States

Pfizer Investigational Site

Arcadia, California, United States

Pfizer Investigational Site

Fullerton, California, United States

Pfizer Investigational Site

Irvine, California, United States

...and 69 more locations