Smoking While on Transdermal Nicotine Replacement Therapy: Effects on Craving and Cessation

Centre for Addiction and Mental Health23 enrolled

Overview

Smoking while on nicotine patches will help subjects to reduce their expired carbon monoxide levels from the levels they were before they started using the patch. Subjects will also decrease their daily consumption of cigarettes.

Subjects who smoke while on an individually dosed tNRT will reduce their expired carbon monoxide levels from pre- to post-treatment conditions. They will also decrease their daily consumption of cigarettes.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Nicotine Dependence

Interventions

NicodermDRUG

Eligibility

Sex: ALLMin age: 19 Years

Medical Language ↔ Plain English

Inclusion Criteria: * at least 19 years of age * male or female * have intention to quit smoking within the next 6 months * smoke 10 or more cigarettes per day Exclusion Criteria: * Pregnant or not using an adequate enough method of birth control to ensure that they are not at risk of becoming pregnant * breastfeeding * have any generalized skin disorders * are in an immediate post-myocardial infarction period or have life-threatening arrhythmias, have severe or worsening angina pectoris or have had a recent cerebral vascular accident * are using additional nicotine replacement therapies or any other smoking cessation pharmacotherapy * any clinically significant ECG abnormalities * any known hypersensitivity to components of the transdermal system

Locations (1)

Centre for Addiction and Mental Health

Toronto, Ontario, Canada

Outcomes

Primary Outcomes

Carbon Monoxide Levels

Expired Co levels were measured to confirm smoking status

Time frame: measured at week 10

Secondary Outcomes

Smoking Cessation

self reported # cigarettes per day

Time frame: Week 10

Data from ClinicalTrials.gov

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