Repeat Nasal Allergen Challenge

Imperial College London22 enrolled

Overview

This is a non-drug, biomarker study to assess the utility of the model of repeated nasal allergen challenges in subjects with atopic rhinitis as a method of inducing an increased response to inhaled allergen, which will more closely resemble the responses seen during the hayfever season.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Hayfever

Interventions

Skin Prick TestPROCEDURE

Nasal allergen challengePROCEDURE

Nasal filter paper placementPROCEDURE

Nasal lavagePROCEDURE

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Male and female subjects with a history of seasonal (intermittent) atopic rhinitis, aged 18-40 years. 2. Otherwise healthy with no health problems that may jeopardize the subjects participating in the study, absence of history of other significant allergies. Exclusion Criteria: 1. Smokers (use of tobacco products in the previous 3 months). 2. Presence of any respiratory disease other than a history of mild stable asthma not requiring treatment and associated with normal lung function (FEV1 \> 80% predicted at screening).

Locations (1)

National Heart & Lung Institute Clinical Studies Unit

London, United Kingdom

Data from ClinicalTrials.gov

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