Effect of Partial Sleep Deprivation on Cognition and Cytokines in Individuals With Major Depression

Zentrum für Integrative Psychiatrie40 enrolled

Overview

40 patients with the diagnosis of major depression are included. There are two interventions: partial sleep deprivation (PSD) and normal night sleep (CTRL). Patients are randomly assigned to PSD-(2 undisturbed nights)-CTRL or CTRL-(2 undisturbed nights)-PSD. Cytokine-status, neuropsychological and psychopathometric status are assessed pre and post each interventional and control condition.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Major Depression

Interventions

partial sleep deprivationBEHAVIORAL

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Major depression * Informed consent Exclusion Criteria: * Known epilepsy or previous unexplained loss of consciousness after sleep deprivation * Bipolar disorder * Acute or chronic inflammatory diseases * Psychosis * Suicidal tendency * Pregnancy or nursing

Locations (1)

Zentrum für Integrative Psychiatrie

Kiel, Germany

Outcomes

Primary Outcomes

cognition

cytokine concentration

Secondary Outcomes

clinical improvement

Data from ClinicalTrials.gov

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