PGI2 Induced Headache and Cerebral Haemodynamics in Healthy Volunteers

Phase 1TerminatedNCT00291395

Danish Headache Center12 enrolled

Overview

Before , during and after intravenous administration of PGI2 we score/measure headache, rCBF, blood flow in middle cerebral artery and diameter of superficial temporal artery/radial artery and correlate that to known patophysiology of headache to see if PGI2 is involved in headache pathophysiology.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

DOUBLE

Enrollment

Conditions

Headache Migraine

Interventions

PGI2DRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy volunteers, Exclusion Criteria: * Primary headache, * headache on the day of investigation, * Hypertension, * hypotension, * pregnant/nursing * Daily intake of medication (except oral contraceptives) * Cardiovascular or CNS disease * Drug/Alcohol abuse * Psychiatric disease

Locations (1)

Danish Headache Center

Glostrup Municipality, Glostrup, Denmark

Outcomes

Primary Outcomes

Headache

Secondary Outcomes

rCBF, blood flow, diameter of STA/RA, HR, BP

Data from ClinicalTrials.gov

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