Simvastatin Effect on End Stage Renal Failure Patients Treated by Peritoneal Dialysis

Federal University of São Paulo30 enrolled

Overview

This study will analyse the effect of simvastatin on endothelium dependent venodilation in chronic renal failure patients treated by peritoneal dialysis. The hypothesis is that patients will have a greater endothelium dependent venodilation after four months of simvastatin use.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Renal Failure, End Stage Peritoneal Dialysis

Interventions

SimvastatinDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * end stage renal failure * peritoneal dialysis * LDL cholesterol \> 100mg/dL * \> 18 years and \< 80 years Exclusion Criteria: * using statin or nitrate * liver disease * diabetes mellitus

Locations (1)

São Lucas Hospital

Porto Alegre, Rio Grande do Sul, Brazil

RECRUITING

Outcomes

Primary Outcomes

endothelial venodilation

Secondary Outcomes

Inflammation markers (C-reactive protein, IL-6, TNF)

Lipoproteins

Oxidative stress

Central Contacts

Maristela Bohlke, MD

CONTACT

55 53 32264098 mbohlke@conesul.com.br

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.