Higher Dose Weekly Topotecan In The Treatment Of Patients With Extensive Stage Small-Cell Lung Cancer

Inclusion Criteria: * Extensive small cell lung cancer with progression after one previous chemotherapy or chemotherapy/radiation therapy regimen * Measurable or evaluable disease * Able to perform activities of daily living with minimal assistance * Adequate bone marrow, liver and kidney function * May have received no more than 3 previous courses of radiation therapy * Give written informed consent prior to study entry Exclusion Criteria: * Patients with limited stage disease * History of a prior malignancy within three years * Female patients who are pregnant or are breast feeding * Significant history of uncontrolled cardiac disease * Myocardial infarction or stroke within six months * Symptomatic peripheral vascular disease * CNS involvement * Serious active infection or underlying medical condition