To Compare the Efficacy and Safety of a Therapy of Tacrolimus With Sirolimus or MMF in Kidney Transplantation.

Inclusion Criteria: * Patients between 18 and 60 years of age and having end stage kidney disease who will undergo primary renal transplantation or retransplantation are eligible for the study. Patients receiving a kidney transplant, from a cadaveric or living donor (not HLA identical) with compatible AB0 blood type can be included. Exclusion Criteria: * Patient has a high immunological risk * Cold ischemia time greater than 30 hours * Patient has significant liver disease * Patient has severe hypercholesterolaemia * Patient is allergic or intolerant to study medication * Patient requires ongoing dosing with corticosteroids. * Patient or donor is known to be HIV positive * Patient with malignancy or history of malignancy